Yakut Science Centre of RAMS and the Government of the Republic Sakha (Yakutia) was founded at the initiative of the first President of the Republic Sakha (Yakutia), M.E. Nikolaev in 2002. The first director of YSC RAMS and the Government of the Republic Sakha (Yakutia) was MD, Professor Alkiviad Isidorovich Ivanov. In 2002-2006 in the YSC RAMS and the Government of the Republic Sakha (Yakutia) 20 research projects were carried out, extensive scientific and organizational work to consolidate and coordinate the scientific potential of the Republic was held. In order to optimize the structure of the research institutions of the Russian Federation in 2007 YSC RAMS and the Government of the Republic Sakha (Yakutia) was transferred to the jurisdiction of the Siberian Branch of RAMS, with the renaming to the Yakut Science Centre of complex medical problems SB RAMS. Structurally FGBU “Yakut Science Centre of complex medical problems” SB RAMS includes 4 departments: scientific – organizational and informational-publishing department, the department of epidemiology of chronic non-infectious diseases, the study of the adaptation mechanisms, molecular genetics, in which there are 10 research laboratories. In the scientific departments of the Center there are 16 doctors, 38 candidates (PhD) of medical and biological sciences. In order to improve the scientific and organizational activity in the FGBU “Yakut Science Centre of complex medical problems” of the Siberian Branch RAMS the Scientific Council, composed of 16 members – leading scientists, experts and managers of large clinics was established. In 2003, the scientific journal “The Yakut Medical Journal”, which later in 2007 joined the list of peer-reviewed journals recommended by Higher Attestation Commission of the Ministry of Education of the Russian Federation for publishing theses, was established. The priority themes for research projects of the Centre since 2007 are: “Atherosclerosis: epidemiology, etiology and pathogenesis and development of measures for the prevention, diagnosis and treatment of the Far North inhabitants on the example of the population of Yakutia”, “The prevalence of cancer pathology and identifying the risk of its development, the establishment of pathogenetic basis of individual sensitivity to anticancer drugs in patients depending on ethnicity “,” Genetic epidemiology of monogenic and common diseases in the ethno-territorial groups of the population of the Republic Sakha (Yakutia) “,” Neuroimmune and endocrine mechanisms of somatic, psychosomatic and reproductive health disorders of the Sakha Republic (Yakutia) adolescents”. We are proud that we have close scientific ties with the Estonian Biocentre (Tartu), the Research Institute of the Brain of Niigata University (Japan), Institute of Medical Genetics, Tomsk Scientific Center, Siberian Branch of the Academy of Medical Sciences (Tomsk), Institute of Biochemistry and Genetics, Ufa Science Center (Ufa), Institute of Therapy, Siberian Branch of RAMS (Novosibirsk), Institute of Oncology, Tomsk Scientific Center, Siberian Branch of the Academy of Medical Sciences (Tomsk), Research Institute of Oncology named after P.A. Gertsen (Moscow), Russian Oncological Centre RAMS named after Blokhin (Moscow), Research Institute of Oncology named after N.N. Petrov (St. Petersburg), Research Institute of Maternal and Child Healthcare of Khabarovsk branch of the Far Eastern Scientific Centre of Physiology and Pathology of Respiration SB RAMS (Khabarovsk) and St. Petersburg State Pediatric Medical Academy (St. Petersburg).